Thermodynamic constraints on kinetic proofreading in biosynthetic pathways
نویسندگان
چکیده
منابع مشابه
Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity.
The specificity with which the genetic code is read in protein synthesis, and with which other highly specific biosynthetic reactions take place, can be increased above the level available from free energy differences in intermediates or kinetic barriers by a process defined here as kinetic proofreading. A simple kinetic pathway is described which results in this proofreading when the reaction ...
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Proofreading mechanisms increase specificity in biochemical reactions by allowing for the dissociation of intermediate complexes. These mechanisms disrupt and reset the reaction to undo errors at the cost of increased time of reaction and free energy expenditure. Here, we draw an analogy between proofreading and microtubule growth which share some of the features described above. Our analogy re...
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REINHART HEINRICH, §, FRANCISCO MONTERO, ¶, EDDA KLIPP, §, THOMAS G. WADDELL,~ and ENRIQUE MELI~NDEZ-HEVIAt § Humboldt-Universitat zu Berlin, Institut for Biologie, Theoretische Biophysik, D-I 0115 Berlin, Germany ¶ Universidad Complutense de Madrid, Departamento de Bioquimica, 28040 Madrid, Spain ~:University of Tennessee, Department of Chemistry, Chattanooga, TN, USA. tUmversidad de la Laguna...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1980
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(80)85063-6